Lifestyle, genes, and cancer

Lifestyle, genes, and cancer
Methods Mol Biol. 2009;472:25-56.

It is estimated that almost 1.5 million people in the USA are diagnosed with cancer every year. However, due to the substantial effect of modifiable lifestyle factors on the most prevalent cancers, it has been estimated that 50% of cancer is preventable.
Physical activity, weight loss, and a reduction in alcohol use can
strongly be recommended for the reduction of breast cancer risk.

Obesity and cancer

Energy intake, physical activity, energy balance, and cancer: epidemiologic evidence
Methods Mol Biol. 2009;472:191-215.

The evidence supports strong links of obesity with the risk of cancers of the colon, rectum, breast (in postmenopausal women), endometrium, kidney (renal cell), and adenocarcinoma of the esophagus. Epidemiologic evidence also indicates that obesity is probably related to cancers of the pancreas, liver, and gallbladder, and aggressive prostate cancer, while it seems that obesity is not associated with lung cancer.

Melatonin, sleep disturbance and cancer risk

Melatonin, sleep disturbance and cancer risk
Sleep Med Rev. 2008 Dec 16.

The pineal hormone melatonin is involved in the circadian regulation and facilitation of sleep, the inhibition of cancer development and growth, and the enhancement of immune function...

A weight loss intervention for african american breast cancer survivors

A weight loss intervention for african american breast cancer survivors, 2006
Prev Chronic Dis. 2009 Jan;6(1):A22. Epub 2008 Dec 15.

CONCLUSION: This is the first published report of Moving Forward, a weight loss intervention designed for African American breast cancer survivors. Although a randomized trial is needed to establish efficacy, the positive results of this intervention suggest that this weight loss intervention may be feasible for African American breast cancer survivors. Lifestyle interventions may reduce the disparities in breast cancer mortality rates.

Dietary Pattern Influences Breast Cancer Prognosis in Women Without Hot Flashes

Dietary Pattern Influences Breast Cancer Prognosis in Women Without Hot Flashes: The Women's Healthy Eating and Living Trial
J Clin Oncol. 2008 Dec 15.

CONCLUSION: A diet with higher vegetable, fruit, and fiber and lower fat intakes than the five-a-day diet may reduce risk of additional events in HF-negative breast cancer survivors. This suggestive finding needs confirmation in a trial in which it is the primary hypothesis.

Alcohol and breast cancer risk

Alcohol and breast cancer risk defined by estrogen and progesterone receptor status: a case-control study
Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):2025-8.

CONCLUSION: This study supports the hypothesis that alcohol is more strongly related to ER+ than to ER- breast tumor.

Dietary carbohydrates, fiber, and breast cancer risk

Dietary carbohydrates, fiber, and breast cancer risk in Chinese women
Am J Clin Nutr. 2008 Dec 3.

CONCLUSION: Our data suggest that a high carbohydrate intake and a diet with a high glycemic load may be associated with breast cancer risk in premenopausal women or women <50 y.